Polymer-Drug Conjugates (eBook, ePUB)

Linker Chemistry, Protocols and Applications
Redaktion: Madan, Jitender; Chopra, Neetu; Chaudhary, Monika; Baldi, Ashish

• Format: ePub

Produktbeschreibung

Polymer-Drug Conjugates: Linker Chemistry, Protocols and Applications discusses important concepts, fundamentals and prospective applications of 'Linker Chemistry' in a clear-and-concise manner. The book provides vital information on chemical entities binding with the drug-polymer complex for targeted drug delivery systems. It highlights roles and significance, different classes and synthetic protocols as well as mechanisms of chemical bond formation in drug-polymer conjugation in drug delivery, also offering insights into the mechanism of polymer interaction with linker and drug molecules by biodegradable chemical bonding.

The protocol of binding with drug molecules is clearly explained and justified with case studies, helping researchers and advanced students in the pharmaceutical sciences understand fundamentals involved and related aspects in molecule designing for effective therapeutic benefits.

• Covers mechanism, protocol and therapeutic significance of Polymer-Drug Conjugates
• Outlines updated methods and techniques to enumerate conjugation with related case studies
• Includes comprehensive compilation of marketed and clinical trial drugs conjugated with polymers or linkers

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in A, B, BG, CY, CZ, D, DK, EW, E, FIN, F, GR, HR, H, IRL, I, LT, L, LR, M, NL, PL, P, R, S, SLO, SK ausgeliefert werden.

Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 420
• Erscheinungstermin: 5. Juli 2023
• Englisch
• ISBN-13: 9780323916905
• Artikelnr.: 68375194

Inhaltsangabe

1. Drug Delivery: The conceptual perspectives and therapeutic applications
2. Rational design of linkers in polymer drug conjugates
3. Exploration of polymers in drug delivery: The structural and functional
considerations
4. Chemistry of conjugation in drug delivery: The prospects of
biodegradable and non-biodegradable bonds
5. Polymer-drug conjugation using ester and orthoester bond: Mechanism,
protocols and applications
6. Polymer-drug linking through amide bonds: The chemistry and applications
in drug delivery
7. Drug-Polymer conjugate tailoring by disulfide linkage and its
exploration in drug distribution
8. Thioether linkage Chemistry: Perspectives and prospects in therapeutic
designing
9. Drug targeting to cancer cells through stimuli responsive imine bonds:
Fascinating aspects of site specificity
10. Carbamate-drug conjugates in drug delivery: Structural and mechanistic
considerations
11. Bonding through phosphodiester moiety: Its implications in
pharmaceutical modifications
12. Enzymatically degradable linkers
13. Dendrimer-Drug conjugates
14. Antibody-Drug conjugates
15. Polymer-Drug Conjugates in Clinical Trials: Challenges, Opportunities
and Future prospects