Pre-Invasive Disease: Pathogenesis and Clinical Management (eBook, PDF)

Redaktion: Fitzgerald, Rebecca C.

• Format: PDF

Produktbeschreibung

There are many books written on cancer, but this monograph focuses on pre-invasive disease. One of the prizes waiting to be won in cancer medicine is to thoroughly understand the processes by which a cell becomes invasive. This quest takes us into the world of stem cells and regulation of gene expression as well as to an understanding of the relative contribution of hereditary factors alongside exposures to environmental agents. This book explores these fundamental concepts as well as considering how advances in disease models combined with -omic technologies and molecular imaging might lead to advances in treatments such as chemoprevention and endoscopic treatments. The final section of the book takes nine specific examples of pre-invasive disease and explores the current state of knowledge and clinical practice as well as looking to the future. This book is written by International experts in their field and should appeal to students and seasoned researchers, to scientists and to clinicians. No prior knowledge of the topic is required to appreciate this text and yet the book charters new territory. New perspectives are given on how our knowledge of cancer development might lead us to reconsider our clinical approach to early detection and prevention of cancer at an individual and population level.

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Produktdetails

• Verlag: Springer New York
• Seitenzahl: 519
• Erscheinungstermin: 14. Oktober 2010
• Englisch
• ISBN-13: 9781441966940
• Artikelnr.: 37347337

Autorenporträt

Rebecca Fitzgerald is a tenured Programme Leader at the Medical Research Council (MRC) Cancer Cell Unit in Cambridge and her research is in Barrett's oesophagus with a particular focus on early cancer detection. She trained at Cambridge University, conducted her doctoral research at Stanford University, California and came to the UK for her post-doctoral research and specialist clinical training at St. Barts and the London Hospitals before returning to Cambridge. Rebecca maintains an clinical active practice as an honorary consultant in Gastroenterology at the University teaching hospital Addenbrooke's and enjoys teaching in her capacity as Director of Studies at Trinity College, Cambridge.

Inhaltsangabe

Guest editorial: Professor Sir Bruce Ponder (AGREED)
1. Epidemiology: public health burden, increasing disease and/or increasing
detection, lag phase, risk factors ? Prof. John Potter Fred Hutchinson
Centre/? Paul Pharoah
2. Pathogenesis:
- cancer stem cells: Prof. Sir Nick Wright, London Research Institute
- inflammation: Lisa Coussens, University California San Francisco
- hereditary factors: Paul Pharoah/Bruce Ponder CRI, Cambridge
- acquired mutations: Doug Hanahan /Robert Weinberg, University California
San Francisco
- Epigenetics: E.G. William Nelson Baltimore/ Steve Meltzer John Hopkins
USA
3. Animal models and other model systems of pre-invasive disease e.g. Tyler
Jacks MIT or Dave Tuveson, CRI cambridge
4. Biomarkers - tissue, serum, fluids: Prof. Brian Reid, Fred Hutchinson
Cancer Center, Seattle or Barbara Weber, GSK Pharmaceuticals
5. Molecular imaging: Professor Kevin Brindle Cambridge Research Institute,
UK or Gary Kelloff NCI, Rockville
6. Issues around screening/surveillance: psychosocial, economic: Dr. Dawn
Provenzale Duke University/ Karen Basen-Engquist MD Anderson texas/ prof
Jane Blazeby Bristol UK
7. Disease specific examples:
Lung: Herman Baltimore
Mouth: Miriam Rosin Vancouver
Oesophagus: Dr Rebecca Fitzgerald, Cambridge UK
Stomach: Dr. Tim Wang, Columbia Univ, New York
Colon: Prof Bert Vogelstein, John Hopkins USA, John Potter, Seattle
Breast: Prof Stephen Duffty, CRUK, UK
Cervix -papsmear/vaccines: TC Wu, Johns Hokins Baltimore
Prostate/bladder: Professor David Neal, CRI Cambridge
8. Chemoprevention: e.g. Prof. John Potter Fred Hutchinson Centre
9. Treatment of early lesions: Jacques Van Dam Stanford / or Jacques
Bergman Amsterdam
10. Common threads: areas for future research and future costs.benefits to
society for early detection: or Michael Sporn Dartmouth Med Sch New
Hampshire, or Gary Kelloff NCI, Maryland or Prof. George Triadafilopoulos,
Stanford