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This book provides a roadmap for creating customized, precision drug delivery systems and advancing personalized medicine by introducing the revolutionary, transformative role of 3D printing technology in medicine. The convergence of advanced manufacturing techniques with the complexities of pharmaceutical formulation has opened new frontiers of innovation, enabling unprecedented precision in drug delivery, tailored therapies, and complex dosage designs. From the creation of personalized drug formulations designed to meet the specific needs of individual patients to the development of…mehr
This book provides a roadmap for creating customized, precision drug delivery systems and advancing personalized medicine by introducing the revolutionary, transformative role of 3D printing technology in medicine.
The convergence of advanced manufacturing techniques with the complexities of pharmaceutical formulation has opened new frontiers of innovation, enabling unprecedented precision in drug delivery, tailored therapies, and complex dosage designs. From the creation of personalized drug formulations designed to meet the specific needs of individual patients to the development of complex, multi-functional drug delivery systems, the chapters within this volume explore a wide array of applications. This book is a groundbreaking resource that delves into the transformative role of 3D printing technology in the pharmaceutical field. Offering insights into customized and precision drug delivery systems, it highlights the synergy between advanced manufacturing techniques and pharmaceutical sciences. The book provides a balanced blend of theory and practical applications, presenting a roadmap for researchers and professionals to integrate 3D printing into their pharmaceutical processes. It discusses the role of innovative materials, cutting-edge technologies, and regulatory perspectives while highlighting the challenges and future trends in the field. By offering contributions from distinguished experts, the book serves as a comprehensive reference for understanding the potential of 3D printing to revolutionize drug delivery and advance personalized medicine.
Readers will find this volume:
Explores cutting-edge 3D printing applications in pharmaceutical sciences, emphasizing precision and innovation;
Covers practical and theoretical insights into customized drug delivery systems using 3D printing;
Includes detailed case studies and emerging trends for academic and industrial professionals;
Features contributions from leading experts and researchers in the field.
Audience
Pharmaceutical scientists, academics, industrial researchers, formulation chemists, biotechnology professionals, and students specializing in pharmaceutical technology, drug delivery systems, and biopharmaceuticals.
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Autorenporträt
Kuldeep Vinchurkar, PhD, works in the Department of Pharmaceutics, Sandip Institute of Pharmaceutical Sciences, affiliated to Savitribai Phule Pune University, Nashik, Maharashtra, India with more than 11 years of research and teaching experience. He has published five books, seven patents, and more than 30 research and review publications in national and international journals. His research interests include 3D printing, artificial intelligence, and novel drug delivery systems, especially gastroretentive drug delivery. Sheetal Mane, PhD is an Assistant Professor of Pharmaceutics at NMT Gujarati College of Pharmacy, Indore, Madhya Pradesh, India and has more than nine years of experience. She has published eight book chapters and 17 research papers in reputed journals and conferences. Her research focuses on novel drug delivery systems. Dinesh Kumar Mishra, PhD is a Professor in the Department of Pharmacy at Guru Ghasidas Vishwavidyalaya with more than 20 years of experience in teaching, research, and administration. He holds three national patents and has authored five books, ten chapters, and more than 80 publications in peer-reviewed national and international journals. He specializes in novel drug delivery systems, particularly lipid-based nanocarriers, transdermal drug delivery, vaccines, and product development.
Inhaltsangabe
Preface xxiii Part I: Fundamentals of 3D Printing in Pharmaceuticals 1 1 Introduction to 3D Printing in Pharmaceuticals 3 Sachin Joshi, Priya Jindal, Balak Das Kurmi, Manish Kumar and Kuldeep Vinchurkar 1.1 Introduction 4 1.2 Categories of 3D Printing Methods in Drug Delivery 6 1.3 3D printing Materials Utilized for Pharmaceuticals 9 1.4 Drug Delivery Technology in 3D Printing 11 1.5 Various Applications of 3D Printing 14 1.6 Possibilities and Difficulties Associated with Applying 3D Printing to Medicine 17 1.7 Conclusion and Recommendations for the Future 18 2 Fundamentals of Pharmaceutical 3D Printing 23 Hardik Rana, Mansi Dholakia, Vimal Patel, Saloni Dalwadi and Kuldeep Vinchurkar 2.1 Design to Object 24 2.2 Types of 3D Printing Material 63 2.3 Key Components of a 3D Printer 68 2.4 Software and Tools for 3D Printing 82 3 Advancements and Applications of 3D Bioprinting in Pharmaceutical Research: A Comprehensive Review 105 Amar Deshpande, Shilpa S. Borkar, Ketki Bhatt, Koustubha S. Pachkor, Satish Polshetttiwar and Jagdish Baheti 3.1 Introduction 106 3.2 Classification of 3D Bioprinting (3DBP) 107 3.3 Methods for Bioprinting 108 3.4 Inkjet-Based Bioprinting 111 3.5 Bioprinting Material 115 3.6 Applications 118 3.7 Advantages 119 3.8 Disadvantages 119 3.9 Future Prospective 120 3.10 Conclusion 120 4 3D Printing of Solid Dosage Forms 129 Ashwin Kuchekar, Prajakta Wagh, Harshavardhan Karnik and Ashwini Gawade 4.1 Introduction 130 4.2 Types of 3D Printing Technologies for Solid Dosage Forms 133 4.3 Materials Used in 3D Printing of Solid Dosage Forms 139 4.4 Design and Formulation Considerations in 3D Printing of Oral Solid Dosage Forms 142 4.5 Manufacturing Process 144 4.6 Quality Control and Regulatory Aspects 151 4.7 Case Studies and Applications 160 4.8 Advantages of 3D Printing in Healthcare Industry 163 4.9 Future Directions and Innovations in 3D Printing for Pharmaceuticals 165 4.10 Conclusion 167 Part II: Applications of 3D Printing in Pharmaceuticals 175 5 3D Printing of Controlled Release Systems 177 Chirag Jain, Shubham Kumar, Shreya Kaul, Manisha Pandey, Bapi Gorain, Najwa Mohamad and Neha Jain 5.1 Introduction 178 5.2 Technologies Utilized in 3D Printing 181 5.3 Recent Advances in 3D Printing of Controlled Release Systems 183 5.4 Technology Lab to Market 193 5.5 Conclusion 200 6 Fabrication of Implants and Medical Devices via Three-Dimensional Printing Technology 207 Ruchira Srivastava and Ayushi Thakur 6.1 Introduction 207 6.2 Various Categories of Three-Dimensional Printing Techniques 209 6.3 Applications in Medical Devices and Implants 217 6.4 Advantages: 3D Printing in Medical Applications 222 6.5 Challenges and Considerations of 3D Printing in Medical Applications 223 6.6 Conclusion 224 7 3D Printing in Drug Delivery System 229 Satish Polshettiwar, Shrikant Dargude, Pranali Polshettiwar, Saloni Ghodmare, Swati Jagdale and Kuldeep Vinchurkar 7.1 Introduction 230 7.2 3D-Printed Drug Delivery System 232 7.3 Applications of 3D Printing in Drug Delivery 245 7.4 Challenges and Limitations 247 7.5 Conclusion 248 8 3D Bioprinting in Pharmaceutical Research 257 Vijaya Padwal, Sachin Kothawade, Sandesh Bole and Kuldeep Vinchurkar 8.1 Introduction 258 8.2 Significance in Pharmaceutical Research 259 8.3 Objectives and Structure 261 8.4 Principles of 3D Bioprinting 262 8.5 Types of Bioprinting 264 8.6 Types of 3D Bioprinters 269 8.7 Materials Used for Bioprinting 273 8.8 Drug Evaluation 279 8.9 Drug Delivery 280 8.10 Customization of Patient-Specific Medications/Personalized Medicine 282 8.11 3D Printing Method and Techniques 283 8.12 Applications of 3D Printing in Personalized Medicines 284 8.13 Conclusion 286 9 Case Studies and Success Stories of Companies Leveraging 3D Printing Technology 295 Debarshi Kar Mahapatra, Kuldeep Vinchurkar and Dinesh Kumar Mishra 9.1 Introduction 296 9.2 Technology and Future 298 9.3 Case and Success Studies of Companies Leveraging 3D Printing Technology 300 9.4 Conclusion 319 Part III: Regulatory, Commercial, and Sustainability Aspects 323 10 Regulatory and Quality Considerations in 3D Printing Technology 325 Chaitanay Vinayak Narayan, Manasvi Saini, Swati Verma, Ajmer Singh Grewal and Kunal Nepali 10.1 Introduction 326 10.2 Patient Safety Concerns with 3D-Printed Medical Products 332 10.3 Legal and Regulatory Framework for 3D Printing of Medical Devices 332 10.4 Regulatory Standards for 3D-Printed Pharmaceuticals 336 10.5 Conclusion 339 11 Intellectual Property Issues in Pharmaceutical 3D Printing 345 Varalaxmi Sagili, Sarad Pawar Naik Bukke, Shanmugam Vippamakula, Buyinza Nichola and Kabali Moses 12 Economic and Commercial Aspects of 3D Printing Technology 365 Sarad Pawar Naik Bukke, Varalaxmi Sagili, Shanmugam Vippamakula, Allan Amooti Ahikiriza and Muhamad Mustafa Mundu 12.1 Overview of 3D Printing Technologies Used in Pharmaceutical Industries 367 12.2 3D Printing Technologies Used in the Manufacture of Drug Delivery Systems in the Pharmaceutical Industry 372 12.3 Development and Commercialization of 3D Printing Technologies in Pharmaceuticals According to Patient Preferences 375 12.4 Current Scenario in Large-Scale Manufacturing of 3D Printing Pharmaceuticals 378 12.5 3D Printing in Personalized Medicine 379 12.6 Future Impacts of 3D Printing on the Pharmaceutical Industrial Sector 380 13 Environment Impact and Sustainability of 3D Printing in Pharmaceuticals 383 Buyinza Nicholas, Varalaxmi Sagili, Sarad Pawar Naik Bukke, Allan Amooti Ahikiriza and Kasolo Daniel 13.1 Introduction 384 13.2 Additives Used in 3D Printing 385 13.3 3D Printing Method and Its Impact on the Environment 390 13.4 Index of Greenness Assessment of Printed Pharmaceuticals 391 13.5 Life Cycle Analysis (LCA) of 3D Printing 393 13.6 Substitution of Energy Sources 394 13.7 Sustainability in 3D Printing 394 13.8 Limitations and Future Perspectives 394 13.9 Conclusion 395 Part IV: Challenges Future Perspectives 397 14 Challenges and Ethical Considerations in 3D Printing Technology 399 Mallamma T., Prakash Goudanavar, Pranav Nayak, Moumita Banerjee and Kuldeep Vinchurkar 14.1 Introduction 400 14.2 Technical Challenges in 3D Printing: Material Limitations 401 14.3 Technical Challenges in 3D Printing: Scalability 404 14.4 Case Studies and Applications 407 14.5 Economic and Business Challenges of 3D Printing Technology: Cost Considerations 408 14.6 Economic and Business Challenges of 3D Printing Technology: Market Adoption 409 14.7 Economic and Business Challenges 411 14.8 Ethical Considerations 413 14.9 Ethical Considerations: Accessibility and Equality in 3D Printing Technology 416 14.10 Legal and Social Challenges in 3D Printing Technology 418 14.11 Healthcare: Case Studies on the Use of 3D Printing in Healthcare 422 14.12 Challenges and Ethical Considerations in 3D Printing Technology: Aerospace and Defense 424 14.13 Challenges and Ethical Considerations in 3D Printing Technology: Consumer Goods 426 14.14 Challenges and Ethical Considerations in 3D Printing Technology: Future Directions and Recommendations 428 14.15 Ethical Challenges in Clinical Applications 430 14.16 Future Recommendations for Policy and Practice 432 14.17 Conclusion 434 15 Future Directions and Emerging Trends in 3D Printing Integrating with Artificial Intelligence and Machine Learning 443 Sutapa Biswas Majee, Sudarshan Singh, Ushasi Das, Dhruti Avlani, Rachayeeta Bera, Shourya Karmakar and Kuldeep Vinchurkar 15.1 Introduction 444 15.2 Basic Concepts of 3D Printing and 3D Bioprinting 445 15.3 Trends in Progress in 3DP and 3DBP 449 15.4 Need for Artificial Intelligence and Machine Learning in 3D Printing Technology in Pharmaceutical and Healthcare Industries 451 15.5 Artificial Intelligence and Machine Learning: Brief Overview 452 15.6 Future Prospects and Emerging Trends in AI-Driven 3D Printing 468 15.7 Conclusion 471 References 472 Index 489
Preface xxiii Part I: Fundamentals of 3D Printing in Pharmaceuticals 1 1 Introduction to 3D Printing in Pharmaceuticals 3 Sachin Joshi, Priya Jindal, Balak Das Kurmi, Manish Kumar and Kuldeep Vinchurkar 1.1 Introduction 4 1.2 Categories of 3D Printing Methods in Drug Delivery 6 1.3 3D printing Materials Utilized for Pharmaceuticals 9 1.4 Drug Delivery Technology in 3D Printing 11 1.5 Various Applications of 3D Printing 14 1.6 Possibilities and Difficulties Associated with Applying 3D Printing to Medicine 17 1.7 Conclusion and Recommendations for the Future 18 2 Fundamentals of Pharmaceutical 3D Printing 23 Hardik Rana, Mansi Dholakia, Vimal Patel, Saloni Dalwadi and Kuldeep Vinchurkar 2.1 Design to Object 24 2.2 Types of 3D Printing Material 63 2.3 Key Components of a 3D Printer 68 2.4 Software and Tools for 3D Printing 82 3 Advancements and Applications of 3D Bioprinting in Pharmaceutical Research: A Comprehensive Review 105 Amar Deshpande, Shilpa S. Borkar, Ketki Bhatt, Koustubha S. Pachkor, Satish Polshetttiwar and Jagdish Baheti 3.1 Introduction 106 3.2 Classification of 3D Bioprinting (3DBP) 107 3.3 Methods for Bioprinting 108 3.4 Inkjet-Based Bioprinting 111 3.5 Bioprinting Material 115 3.6 Applications 118 3.7 Advantages 119 3.8 Disadvantages 119 3.9 Future Prospective 120 3.10 Conclusion 120 4 3D Printing of Solid Dosage Forms 129 Ashwin Kuchekar, Prajakta Wagh, Harshavardhan Karnik and Ashwini Gawade 4.1 Introduction 130 4.2 Types of 3D Printing Technologies for Solid Dosage Forms 133 4.3 Materials Used in 3D Printing of Solid Dosage Forms 139 4.4 Design and Formulation Considerations in 3D Printing of Oral Solid Dosage Forms 142 4.5 Manufacturing Process 144 4.6 Quality Control and Regulatory Aspects 151 4.7 Case Studies and Applications 160 4.8 Advantages of 3D Printing in Healthcare Industry 163 4.9 Future Directions and Innovations in 3D Printing for Pharmaceuticals 165 4.10 Conclusion 167 Part II: Applications of 3D Printing in Pharmaceuticals 175 5 3D Printing of Controlled Release Systems 177 Chirag Jain, Shubham Kumar, Shreya Kaul, Manisha Pandey, Bapi Gorain, Najwa Mohamad and Neha Jain 5.1 Introduction 178 5.2 Technologies Utilized in 3D Printing 181 5.3 Recent Advances in 3D Printing of Controlled Release Systems 183 5.4 Technology Lab to Market 193 5.5 Conclusion 200 6 Fabrication of Implants and Medical Devices via Three-Dimensional Printing Technology 207 Ruchira Srivastava and Ayushi Thakur 6.1 Introduction 207 6.2 Various Categories of Three-Dimensional Printing Techniques 209 6.3 Applications in Medical Devices and Implants 217 6.4 Advantages: 3D Printing in Medical Applications 222 6.5 Challenges and Considerations of 3D Printing in Medical Applications 223 6.6 Conclusion 224 7 3D Printing in Drug Delivery System 229 Satish Polshettiwar, Shrikant Dargude, Pranali Polshettiwar, Saloni Ghodmare, Swati Jagdale and Kuldeep Vinchurkar 7.1 Introduction 230 7.2 3D-Printed Drug Delivery System 232 7.3 Applications of 3D Printing in Drug Delivery 245 7.4 Challenges and Limitations 247 7.5 Conclusion 248 8 3D Bioprinting in Pharmaceutical Research 257 Vijaya Padwal, Sachin Kothawade, Sandesh Bole and Kuldeep Vinchurkar 8.1 Introduction 258 8.2 Significance in Pharmaceutical Research 259 8.3 Objectives and Structure 261 8.4 Principles of 3D Bioprinting 262 8.5 Types of Bioprinting 264 8.6 Types of 3D Bioprinters 269 8.7 Materials Used for Bioprinting 273 8.8 Drug Evaluation 279 8.9 Drug Delivery 280 8.10 Customization of Patient-Specific Medications/Personalized Medicine 282 8.11 3D Printing Method and Techniques 283 8.12 Applications of 3D Printing in Personalized Medicines 284 8.13 Conclusion 286 9 Case Studies and Success Stories of Companies Leveraging 3D Printing Technology 295 Debarshi Kar Mahapatra, Kuldeep Vinchurkar and Dinesh Kumar Mishra 9.1 Introduction 296 9.2 Technology and Future 298 9.3 Case and Success Studies of Companies Leveraging 3D Printing Technology 300 9.4 Conclusion 319 Part III: Regulatory, Commercial, and Sustainability Aspects 323 10 Regulatory and Quality Considerations in 3D Printing Technology 325 Chaitanay Vinayak Narayan, Manasvi Saini, Swati Verma, Ajmer Singh Grewal and Kunal Nepali 10.1 Introduction 326 10.2 Patient Safety Concerns with 3D-Printed Medical Products 332 10.3 Legal and Regulatory Framework for 3D Printing of Medical Devices 332 10.4 Regulatory Standards for 3D-Printed Pharmaceuticals 336 10.5 Conclusion 339 11 Intellectual Property Issues in Pharmaceutical 3D Printing 345 Varalaxmi Sagili, Sarad Pawar Naik Bukke, Shanmugam Vippamakula, Buyinza Nichola and Kabali Moses 12 Economic and Commercial Aspects of 3D Printing Technology 365 Sarad Pawar Naik Bukke, Varalaxmi Sagili, Shanmugam Vippamakula, Allan Amooti Ahikiriza and Muhamad Mustafa Mundu 12.1 Overview of 3D Printing Technologies Used in Pharmaceutical Industries 367 12.2 3D Printing Technologies Used in the Manufacture of Drug Delivery Systems in the Pharmaceutical Industry 372 12.3 Development and Commercialization of 3D Printing Technologies in Pharmaceuticals According to Patient Preferences 375 12.4 Current Scenario in Large-Scale Manufacturing of 3D Printing Pharmaceuticals 378 12.5 3D Printing in Personalized Medicine 379 12.6 Future Impacts of 3D Printing on the Pharmaceutical Industrial Sector 380 13 Environment Impact and Sustainability of 3D Printing in Pharmaceuticals 383 Buyinza Nicholas, Varalaxmi Sagili, Sarad Pawar Naik Bukke, Allan Amooti Ahikiriza and Kasolo Daniel 13.1 Introduction 384 13.2 Additives Used in 3D Printing 385 13.3 3D Printing Method and Its Impact on the Environment 390 13.4 Index of Greenness Assessment of Printed Pharmaceuticals 391 13.5 Life Cycle Analysis (LCA) of 3D Printing 393 13.6 Substitution of Energy Sources 394 13.7 Sustainability in 3D Printing 394 13.8 Limitations and Future Perspectives 394 13.9 Conclusion 395 Part IV: Challenges Future Perspectives 397 14 Challenges and Ethical Considerations in 3D Printing Technology 399 Mallamma T., Prakash Goudanavar, Pranav Nayak, Moumita Banerjee and Kuldeep Vinchurkar 14.1 Introduction 400 14.2 Technical Challenges in 3D Printing: Material Limitations 401 14.3 Technical Challenges in 3D Printing: Scalability 404 14.4 Case Studies and Applications 407 14.5 Economic and Business Challenges of 3D Printing Technology: Cost Considerations 408 14.6 Economic and Business Challenges of 3D Printing Technology: Market Adoption 409 14.7 Economic and Business Challenges 411 14.8 Ethical Considerations 413 14.9 Ethical Considerations: Accessibility and Equality in 3D Printing Technology 416 14.10 Legal and Social Challenges in 3D Printing Technology 418 14.11 Healthcare: Case Studies on the Use of 3D Printing in Healthcare 422 14.12 Challenges and Ethical Considerations in 3D Printing Technology: Aerospace and Defense 424 14.13 Challenges and Ethical Considerations in 3D Printing Technology: Consumer Goods 426 14.14 Challenges and Ethical Considerations in 3D Printing Technology: Future Directions and Recommendations 428 14.15 Ethical Challenges in Clinical Applications 430 14.16 Future Recommendations for Policy and Practice 432 14.17 Conclusion 434 15 Future Directions and Emerging Trends in 3D Printing Integrating with Artificial Intelligence and Machine Learning 443 Sutapa Biswas Majee, Sudarshan Singh, Ushasi Das, Dhruti Avlani, Rachayeeta Bera, Shourya Karmakar and Kuldeep Vinchurkar 15.1 Introduction 444 15.2 Basic Concepts of 3D Printing and 3D Bioprinting 445 15.3 Trends in Progress in 3DP and 3DBP 449 15.4 Need for Artificial Intelligence and Machine Learning in 3D Printing Technology in Pharmaceutical and Healthcare Industries 451 15.5 Artificial Intelligence and Machine Learning: Brief Overview 452 15.6 Future Prospects and Emerging Trends in AI-Driven 3D Printing 468 15.7 Conclusion 471 References 472 Index 489
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