Fred Bunz

Principles of Cancer Genetics (eBook, PDF)

• Format: PDF

Produktbeschreibung

Cancer genetics is a field of daunting breadth and depth. The literature describes hundreds of genes and genetic alterations that are variably associated with again as many disease states and risk factors. Integrating these disparate pieces of highly specialized information is challenging for the professional scientist and student alike. This concise guidebook consolidates the main concepts of the cancer gene theory, and provides a framework for understanding the genetic basis of cancer. The book is focused on the most highly representative genes that underlie the most common cancers and highlights new frontiers in gene-based diagnosis and therapy. Primary attention is devoted to the origins of cancer genes and the application of evolutionary theory to explain why the cell clones that harbor cancer genes tend to expand.

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Produktdetails

• Verlag: Springer Netherlands
• Seitenzahl: 326
• Erscheinungstermin: 20. Dezember 2007
• Englisch
• ISBN-13: 9781402067846
• Artikelnr.: 43730607

Autorenporträt

Fred Bunz, M.D., Ph.D is a research scientist, lecturer and author at the Johns Hopkins School of Medicine. A native of Long Beach, New York, Dr. Bunz attended Stony Brook University and received training in cancer genetics at Cold Spring Harbor Laboratory and Johns Hopkins University, which he joined as a fellow of the Howard Hughes Medical Institute. Dr. Bunz currently heads a laboratory at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins that investigates the effects of DNA damage and pathogens on cancer cells and normal cells. He lives in Baltimore with his family.

Inhaltsangabe

Chapter 1. The Genetic Basis of Cancer.- Chapter 2. Oncogenes.- Chapter 3. Tumor Suppressor Genes.- Chapter 4. Genetic Instability and Cancer.- Chapter 5. Cancer Genomes.- Chapter 6. Cancer Gene Pathways.- Chapter 7. Cancer and the Immune System.- Chapter 8. Common Cancers and Their Genetic Alterations.- Chapter 9. Cancer Detection and Prognostication.- Chapter 10. Cancer Therapy.

Rezensionen

From the reviews:
"The book is exceptional in its clarity and scope of presentation. ... Bunz focuses on a laser with short clear descriptions and presentations. ... All in all a superb little gem worth being on many a desk. I find it is worth going back to from time to time." (Philosophy, Religion and Science Book Reviews, bookinspections.wordpress.com, December, 2013)