Principles of Mucosal Immunology (eBook, PDF)

Redaktion: Smith, Phillip; Society for Mucosal Immunology; Macdonald, Thomas; Blumberg, Richard

• Format: PDF

Produktbeschreibung

This respected graduate-level textbook provides comprehensive and accessible coverage of the basic and clinical aspects of the mucosal immune system, addressing the major components of the mucosal barrier ¿ gastrointestinal, upper and lower respiratory, ocular, and genitourinary mucosal immune systems ¿ in a highly user-friendly style. The editors of and contributors to the book, all internationally-recognized leaders, present the current principles, concepts, and basic processes involved in mucosal immunology, mucosal diseases, and host defense at mucosal surfaces. Topics discussed include the development and structure of the mucosal immune system and its cellular constituents, host-microbe relationships, infection, mucosal diseases, and vaccines. The second edition has been carefully updated throughout to reflect the latest developments from clinical research and key literature has been fully updated.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 614
• Erscheinungstermin: 21. April 2020
• Englisch
• ISBN-13: 9781000754490
• Artikelnr.: 59279078

Autorenporträt

The Society for Mucosal Immunology advances research and education related to the field of mucosal immunology. Phillip D. Smith, MD, is Professor of Medicine and Microbiology and The Mary J Bradford Professor of Gastroenterology, Department of Medicine at the University of Alabama at Birmingham, Alabama. Thomas T. MacDonald, PhD, FRCPath, FMedSci, is Dean for Research and Professor of Immunology, Centre for Immunology and Infectious Disease, at Barts and the London School of Medicine and Dentistry, London. Richard S. Blumberg, MD, is Professor of Medicine, Harvard Medical School, Chief, Gastroenterology and Hepatology Division, Brigham and Women's Hospital, Boston, Massachusetts.

Inhaltsangabe

DEVELOPMENT AND STRUCTURE OF MUCOSAL TISSUE. Overview of the mucosal immune
system structure. Phylogeny of the mucosal immune system. Immunologic and
functional differences among individual compartments of the mucosal immune
system. Secreted effectors of the innate mucosal barrier. CELLULAR
CONSTITUENTS OF MUCOSAL IMMUNE SYSTEMS AND THEIR FUNCTION IN MUCOSAL
HOMEOSTASIS. Immune function of epithelial cells. Intraepithelial T cells:
Specialized T cells at epithelial surfaces. T lymphocyte populations within
the lamina propria. Innate lymphoid cells. Role of regulatory T cells in
mucosal immunity. Mucosal B cells and their function. Secretory
immunoglobulins and their transport. Role of dendritic cells in integrating
immune responses to luminal antigens. Intestinal macrophages in defense of
the mucosa. Mucosal basophils, eosinophils, and mast cells. M cells and the
follicle-associated epithelium. Lymphocyte trafficking from inductive sites
to effector sites. Mucosal tolerance. MICROBIAL COMMENSALISM. Recognition
of microbe-associated molecular patterns by pattern recognition receptors.
Commensal microbiota and its relationship to homeostasis and disease.
GENITOURINARY TRACT. The immune system of the genitourinary tract. Mucosal
immune responses to microbes in genital tract. NOSE, AIRWAYS, ORAL CAVITY,
AND EYES. Nasopharyngeal and oral immune system. Bronchus-associated
lymphoid tissue and immune-mediated respiratory diseases. Ocular surface as
mucosal immune site. INFECTIOUS DISEASES OF MUCOSAL SURFACES. Mucosal
interactions with enteropathogenic bacteria. infection. Mucosal responses
to helminth infections. Viral infections. Infection-driven periodontal
disease. Mucosal vaccine strategies. SPECIFIC IMMUNE-MEDIATED DISEASES OF
MUCOSAL SURFACES. Celiac disease. IgA nephropathy. Mucosal manifestations
of immunodeficiencies. Inflammatory bowel disease. Food allergies and
eosinophilic gastrointestinal diseases.