Programmed Cell Death in Animals and Plants (eBook, PDF)

Redaktion: Bryant, John; Hughes, S. G.; Garland, Jeff

• Format: PDF

Produktbeschreibung

This title, the 52nd in symposium series, presents a comprehensive review of apoptosis and features contributions from many internationally recognised authors. The book is the first to integrate programmed cell death in plants, invertebrates and vertebrates. Rapid publication ensures that the very latest research is included.

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 328
• Erscheinungstermin: 24. Dezember 2021
• Englisch
• ISBN-13: 9781000102345
• Artikelnr.: 63134391

Autorenporträt

School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK. School of Biological Sciences, University of Exeter, Exeter, EX 4 4QG, UK.

Inhaltsangabe

Contributors
Abbreviations
Preface
1 Apoptotic cell death: from worms to wombats ... but what about the weeds? 1 /M.O. Hengartnerand J.A. Bryant
Caenorhabditis elegans: the worm that turned ... into a model multicellular eukaryote
The molecular mechanisms of programmed cell death in Caenorhabditis elegans
Comparison with mammalian apoptosis
Plants, from Arabidopsis to Zinnia
General conclusions
2 Caspases
at the cutting edge of cell death /H.R. Stennicke
Introduction
Caspases and their properties
Structure of the caspases
Activation and regulation of the caspases
Evolution of the caspases
3 Modulation of death receptor signalling /P. Schneider and J.Tschopp
Introduction
Death receptors and apoptosis
Activation of death receptors by death ligands
Decoy receptors
Inhibition of death receptor by FLIP
Conclusion
4 The role of the Bcl
2 family in the modulation of apoptosis /C. Pepper and P. Bentley
Introduction
Bcl
2 family: life or death promoters
Function of the Bcl
2 family proteins
Cellular control of Bcl
2 family proteins
Over
expression of Bcl
2 family proteins and chemoresistance
Drug resistance in B
CLL
Strategies for inhibiting Bcl
2 function in B
CLL
Conclusions
5 The role of granzymes and serpins in regulating cell growth and death /P. Coughlin, E. Morris and L. Hampson
Introduction
Induction of apoptosis by cytotoxic T cells and natural killer cells
How does granzyme B gain access to the interior of target cells?
Molecular targets of granzyme B
Regulation of granzyme B activity
The intracellular regulation of granzyme B by PI
9
The role of intracellular serpins in cell growth and death
Conclusions
6 Mitochondria and cell death: a pore way to die? /A.P. Halestrap, J.P. Gillespie, A. O'Toole and E. Doran
Introduction
The mitochondrial permeability transition
Mitochondria and apoptosis
7 Regulation of apoptosis by cell metabolism