Gogia, Sandeep Kumar Singh, Vidyadhara Devarunda Jaganath

Protein Misfolding in Neurodegenerative Diseases (eBook, ePUB)

• Format: ePub

Produktbeschreibung

Approx.280 pages - Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders - Describes methods for detection and analysis of protein aggregates - Features advancements in therapeutics and emerging techniques to treat these disorders - Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington's and other related proteinopathies

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 300
• Erscheinungstermin: 11. März 2025
• Englisch
• ISBN-13: 9780443187179
• Artikelnr.: 73661966

Autorenporträt

Dr. Gogia is a Post-Doctoral Associate at Yale. Having completed her PhD degree at the University of Dayton, and Cornell University's International Agriculture and Rural Development Program (IARD) she was awarded the Gerald L. Willis Award of Excellence for Outstanding Teaching in 2019. Her current work focuses on understanding cellular and molecular mechanisms underlying polyglutamine diseases, namely the identification and validation of genetic modifiers which can serve as potential therapeutic targets and can ameliorate the onset or progression of neurodegenerative diseases.

Inhaltsangabe

1. Maintenance of balanced proteome homeostasis
2. Determinants of protein misfolding, aggregation in neuronal cell death
3. Classification, structure, and function of protein aggregates in
proteinopathies
4. Protein aggregation and cellular and molecular mechanisms in
neurodegenerative disease
5. Advances in methods to detect and study protein aggregation
6. Organelle specific protein quality control
7. Molecular chaperones and co-chaperones in proteostasis
8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal
proteolytic pathways
9. Alterations in protein quality control
10. Alternate mechanisms to maintain proteome homeostasis
11. Advances in developing novel therapeutics, strategies, approaches and
use of emerging techniques
12. Challenges in translating laboratory findings to drug development
13. Advancements in drug delivery technologies for protein misfolding
diseases