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Quality in Laboratory Hemostasis and Thrombosis Second Edition Edited by Steve Kitchen, Clinical Scientist, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA F. Eric Preston, Emeritus Professsor of…mehr
Quality in Laboratory Hemostasis and Thrombosis Second Edition Edited by Steve Kitchen, Clinical Scientist, Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA F. Eric Preston, Emeritus Professsor of Haematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK The hemostasis laboratory has a vital role in the diagnosis and management of patients with familial and acquired hemorrhagic and thrombotic disorders. Rapid changes in the number and complexity of tests in this discipline have presented challenges for laboratories, as they develop quality programs for the oversight of this testing. Quality in Laboratory Hemostasis and Thrombosis has been completely revised and updated to reflect the changing process of managing quality. The second edition provides information on all aspects of testing, from pre-analytic to analytic and result reporting, in addition to external quality assurance. Chapters throughout the book include the development of global guidelines for methods, as well as the preparation of international standard plasmas and reagents. Designed to capture the elements of quality at all levels of the practice of laboratory hemostasis and thrombosis, this book will guide the reader through the development of a quality program to support all activities in the hemostasis laboratory, both simple and complex. Titles of related interest Lee: Textbook of Hemophilia, 2e (2010) ISBN 9781405169141 Federici: Von Willebrand Disease: Basic and Clinical Aspects, 1e (2011) ISBN 9781405195126 Ma: Hemophilia and Hemostasis: A Case Based Approach to Management, 2e (2012) ISBN 9780470659762
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Autorenporträt
Dr Steve Kitchen, Clinical Scientist, Sheffield Hemophila and Thromobosis Centre, Royal Hallamshire Hospital and Scientific Director, UK National External Quality Assessment Scheme (FQAS) for Blood Coagulation, Scientific Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulation, Sheffield, UK. John D Olson, Professor and Vice Chair for Clinical Affairs, Department of Pathology, University of Texas Health Sciences Centre, San Antonio, Texas, USA. F. Eric Preston, Emeritus Professsor of Hematology, University of Sheffield and Director, WHO and WFH International External Quality Assessment Programs for Blood Coagulations, Sheffield, UK.
Inhaltsangabe
Contributors vii Foreword x Preface xii Steve Kitchen John D. Olson & F. Eric Preston Part 1: General Quality Program 1 General quality planning in the hemostasis laboratory 3 John D. Olson 2 Hemostasis test validation performance and reference intervals: international recommendations and guidelines 12 RichardA.Marlar 3 Causes of errors in medical laboratories 22 Giuseppe Lippi & Emmanuel J. Favaloro 4 International standards in hemostasis 32 Trevor W. Barrowcliffe & Anthony R. Hubbard 5 Sample integrity and preanalytical variables 45 Dorothy (Adcock) Funk 6 Internal quality control in the hemostasis laboratory 57 Steve Kitchen F. Eric Preston & John D. Olson 7 External quality assessment in hemostasis: its importance and significance 65 F. Eric Preston Steve Kitchen & Alok Srivastava 8 The unique challenges of hemostatic testing in children 77 M. Patricia Massicotte Mary E. Bauman Vanessa Chan & Anthony K.C. Chan Part 2: Quality in Coagulation Testing 9 Initial evaluation of hemostasis: reagent and method selection 95 Wayne L. Chandler 10 Assay of factor VIII and other clotting factors 105 Steve Kitchen & F. Eric Preston 11 Application of molecular genetics to the investigation of inherited bleeding disorders 115 Stefan Lethagen Morten Dunø & Lars Bo Nielsen 12 Detecting and quantifying acquired functional inhibitors in hemostasis 124 Bert Verbruggen Myriam Dardikh & Britta Laros-van Gorkom 13 Standardization of d-dimer testing 136 Guido Reber & Philippe de Moerloose 14 Point-of-care testing in hemostasis 147 Chris Gardiner Dianne Kitchen Samuel Machin & Ian Mackie Part 3: Quality in Testing for Platelet Function and von Willebrand Disease 15 Diagnostic assessment of platelet function 159 Paquita Nurden Alan Nurden & Martine Jandrot-Perrus 16 Laboratory evaluation of heparin-induced thrombocytopenia 174 Theodore (Ted) E. Warkentin & Jane C. Moore 17 Laboratory evaluation of von Willebrand disease: phenotypic analysis 192 Emmanuel J. Favaloro 18 Laboratory analysis of von Willebrand disease: molecular analysis 204 Anne C. Goodeve & Ian R. Peake Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation 19 Quality issues in heritable thrombophilia testing 219 Isobel D. Walker & Ian Jennings 20 Evaluation of antiphospholipid antibodies 233 Michael Greaves 21 Monitoring heparin therapy 244 Marilyn Johnston 22 Monitoring oral anticoagulant therapy with vitamin K antagonists 253 Armando Tripodi 23 Monitoring new anticoagulants 264 Elaine Gray & Trevor W. Barrowcliffe Index 273
Contributors vii Foreword x Preface xii Steve Kitchen John D. Olson & F. Eric Preston Part 1: General Quality Program 1 General quality planning in the hemostasis laboratory 3 John D. Olson 2 Hemostasis test validation performance and reference intervals: international recommendations and guidelines 12 RichardA.Marlar 3 Causes of errors in medical laboratories 22 Giuseppe Lippi & Emmanuel J. Favaloro 4 International standards in hemostasis 32 Trevor W. Barrowcliffe & Anthony R. Hubbard 5 Sample integrity and preanalytical variables 45 Dorothy (Adcock) Funk 6 Internal quality control in the hemostasis laboratory 57 Steve Kitchen F. Eric Preston & John D. Olson 7 External quality assessment in hemostasis: its importance and significance 65 F. Eric Preston Steve Kitchen & Alok Srivastava 8 The unique challenges of hemostatic testing in children 77 M. Patricia Massicotte Mary E. Bauman Vanessa Chan & Anthony K.C. Chan Part 2: Quality in Coagulation Testing 9 Initial evaluation of hemostasis: reagent and method selection 95 Wayne L. Chandler 10 Assay of factor VIII and other clotting factors 105 Steve Kitchen & F. Eric Preston 11 Application of molecular genetics to the investigation of inherited bleeding disorders 115 Stefan Lethagen Morten Dunø & Lars Bo Nielsen 12 Detecting and quantifying acquired functional inhibitors in hemostasis 124 Bert Verbruggen Myriam Dardikh & Britta Laros-van Gorkom 13 Standardization of d-dimer testing 136 Guido Reber & Philippe de Moerloose 14 Point-of-care testing in hemostasis 147 Chris Gardiner Dianne Kitchen Samuel Machin & Ian Mackie Part 3: Quality in Testing for Platelet Function and von Willebrand Disease 15 Diagnostic assessment of platelet function 159 Paquita Nurden Alan Nurden & Martine Jandrot-Perrus 16 Laboratory evaluation of heparin-induced thrombocytopenia 174 Theodore (Ted) E. Warkentin & Jane C. Moore 17 Laboratory evaluation of von Willebrand disease: phenotypic analysis 192 Emmanuel J. Favaloro 18 Laboratory analysis of von Willebrand disease: molecular analysis 204 Anne C. Goodeve & Ian R. Peake Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation 19 Quality issues in heritable thrombophilia testing 219 Isobel D. Walker & Ian Jennings 20 Evaluation of antiphospholipid antibodies 233 Michael Greaves 21 Monitoring heparin therapy 244 Marilyn Johnston 22 Monitoring oral anticoagulant therapy with vitamin K antagonists 253 Armando Tripodi 23 Monitoring new anticoagulants 264 Elaine Gray & Trevor W. Barrowcliffe Index 273
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