Receptor - Based Drug Design (eBook, PDF)

Redaktion: Leff, Paul

• Format: PDF

Produktbeschreibung

Employing a wide range of examples from G-protein-coupled receptors and ligand-gated ion channels, this detailed, single-source reference illustrates the principles of pharmacological analysis and receptor classification that are the basis of rational drug design. Explains the experimental and theoretical methods used to characterize interactio

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 400
• Erscheinungstermin: 10. April 1998
• Englisch
• ISBN-13: 9781420001136
• Artikelnr.: 54272114

Autorenporträt

Leff Paul

Inhaltsangabe

Introduction
James Black Principles and Measurement of Drug-Receptor Interactions The Characterization and Classification of Receptors
Patrick P. A. Humphrey Functional Methods for Quantifying Agonists and Antagonists
Iain G. Dougall Quantification of Receptor Interactions Using Binding Methods
Sebastian Lazareno Drug Analysis Based on Signaling Responses to G-Protein-Coupled Receptors
T. Kendall Harden
José L. Boyer
and Robert W. Dougherty The Use of Electrophysiology to Improve Understanding of Drug-Receptor Interactions
John G. Connolly and Charles Kennedy Receptor-Based Drugs in Medicine Selective Adrenergic and Glucocorticoid Treatments for Asthma
David Jack Serotonin 5-HT1B/D Receptor Agonists
Graeme R. Martin Histamine H2-Receptor Antagonists
Michael E. Parsons Angiotensin Antagonists
Mark J. Robertson Experimental and Emerging Drugs -Adrenoceptor Agonists and Antagonists
J. Paul Hieble and Robert R. Ruffolo
Jr. P2U-Purinoceptor Agonists: Emerging Therapy for Pulmonary Diseases
Eduardo R. Lazarowski
William C. Watt
T. Kendall Harden
and Richard C. Boucher Muscarinic Receptor Antagonists Pharmacological and Therapeutic Utility
Richard M. Eglen NMDA Receptor Antagonists
John A. Kemp and James N. C. Kew New Trends in Drug Design Computational Chemistry in Receptor-Based Drug Design
Ad P. IJzerman
Eleonora M. van der Wenden
and Wilma Kuipers Recombinant G-Protein-Coupled Receptors as Screening Tools for Drug Discovery
A. Donny Strosberg and Prabhavathi B. Fernandes Inverse Agonists and G-Protein-Coupled Receptors
Richard A. Bond and Michel Bouvier