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Ribozymes Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world's top professionals in the field Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject. Ribozymes is organized into six major parts. It starts by describing general principles…mehr
Provides comprehensive coverage of a core field in the molecular biosciences, bringing together decades of knowledge from the world's top professionals in the field
Timely and unique in its breadth of content, this all-encompassing and authoritative reference on ribozymes documents the great diversity of nucleic acid-based catalysis. It integrates the knowledge gained over the past 35 years in the field and features contributions from virtually every leading expert on the subject.
Ribozymes is organized into six major parts. It starts by describing general principles and strategies of nucleic acid catalysis. It then introduces naturally occurring ribozymes and includes the search for new catalytic motifs or novel genomic locations of known motifs. Next, it covers the development and design of engineered ribozymes, before moving on to DNAzymes as a close relative of ribozymes. The next part examines the use of ribozymes for medicinal and environmental diagnostics, as well as for therapeutic tools. It finishes with a look at the tools and methods in ribozyme research, including the techniques and assays for structural and functional characterization of nucleic acid catalysts.
The first reference to tie together all aspects of the multi-faceted field of ribozymes
Features more than 30 comprehensive chapters in two volumes
Covers the chemical principles of RNA catalysis; naturally occurring ribozymes, engineered ribozymes; DNAzymes; ribozymes as tools in diagnostics and therapy, and tools and methods to study ribozymes
Includes first-hand accounts of concepts, techniques, and applications by a team of top international experts from leading academic institutions
Dedicates half of its content to methods and practical applications, ranging from bioanalytical tools to medical diagnostics to therapeutics
Ribozymes is an unmatched resource for all biochemists, biotechnologists, molecular biologists, and bioengineers interested in the topic.
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Autorenporträt
Sabine Müller is Full Professor for Biochemistry/Bioorganic Chemistry at University Greifswald (Germany), and is a member of the Leibniz-Sozietät der Wissenschaften zu Berlin and of AcademiaNet. She has been working in the field of RNA engineering and has made important contributions to ribozyme research. Benoît Masquida is a Research Director at Centre National de la Recherche Scientifique, and carries on research and teaching activities at the University of Strasbourg (France). He made important contributions in the field of RNA structural biology, notably through identification of new RNA folds and their evolutionary relationships. Wade Winkler is Professor of Cell Biology and Molecular Genetics at the University of Maryland (USA), and has authored multiple influential publications on the different types of regulatory RNAs in bacteria.
Inhaltsangabe
INTRODUCTION The chemical principles of RNA catalysis
NATURALLY OCCURRING RIBOZYMES Biological roles of self-cleaving ribozymes Chemical mechanisms of the nucleolytic ribozymes The glmS ribozyme and its multifunctional coenzyme glucosamine-6-phosphate The lariat capping ribozyme Self-splicing group II introns The Spliceosome: an RNA-Protein ribozyme derived from ancient mobile genetic elements The ribosome and protein synthesis The RNase P ribozyme Ribozyme Discovery in Bacteria Small self-cleaving ribozymes in the genomes of vertebrates
ENGINEERED RIBOZYMES Phosphoryl transfer ribozymes RNA replication and the RNA polymerase ribozyme Maintenance of genetic information in the first ribocell Ribozyme-catalyzed RNA recombination Engineering of hairpin ribozymes for RNA processing reactions Engineering of the Neurospora Varkud Satellite ribozyme for cleavage of non-natural stem-loop substrates Chemical modifications in natural and engineered ribozymes Ribozymes for regulation of gene expression Development of flexizyme aminoacylation ribozymes and their applications In vitro selected (deoxy)ribozymes that catalyze carbon-carbon-bond formation Nucleic acid catalyzed RNA ligation and labeling
DNAZYMES The chemical repertoire of DNA enzymes Light-utilizing DNAzymes Applications of DNAzymes in computing and nanotechnology.
RIBOZYMES AS TOOLS IN DIAGNOSTICS AND THERAPY Optimization of antiviral ribozymes DNAzymes as Biosensors Compartmentalization-based technologies for in vitro selection and evolution of ribozymes and light-up RNA aptamers
TOOLS AND METHODS TO STUDY RIBOZYMES Elucidation of ribozyme mechanisms at the example of the Pistol ribozyme Strategies for crystallization of natural ribozymes NMR spectroscopic investigation of ribozymes Studying Ribozymes with Electron Paramagnetic Resonance Spectroscopy Computational modeling methods for 3D structure prediction of ribozymes
INTRODUCTION The chemical principles of RNA catalysis
NATURALLY OCCURRING RIBOZYMES Biological roles of self-cleaving ribozymes Chemical mechanisms of the nucleolytic ribozymes The glmS ribozyme and its multifunctional coenzyme glucosamine-6-phosphate The lariat capping ribozyme Self-splicing group II introns The Spliceosome: an RNA-Protein ribozyme derived from ancient mobile genetic elements The ribosome and protein synthesis The RNase P ribozyme Ribozyme Discovery in Bacteria Small self-cleaving ribozymes in the genomes of vertebrates
ENGINEERED RIBOZYMES Phosphoryl transfer ribozymes RNA replication and the RNA polymerase ribozyme Maintenance of genetic information in the first ribocell Ribozyme-catalyzed RNA recombination Engineering of hairpin ribozymes for RNA processing reactions Engineering of the Neurospora Varkud Satellite ribozyme for cleavage of non-natural stem-loop substrates Chemical modifications in natural and engineered ribozymes Ribozymes for regulation of gene expression Development of flexizyme aminoacylation ribozymes and their applications In vitro selected (deoxy)ribozymes that catalyze carbon-carbon-bond formation Nucleic acid catalyzed RNA ligation and labeling
DNAZYMES The chemical repertoire of DNA enzymes Light-utilizing DNAzymes Applications of DNAzymes in computing and nanotechnology.
RIBOZYMES AS TOOLS IN DIAGNOSTICS AND THERAPY Optimization of antiviral ribozymes DNAzymes as Biosensors Compartmentalization-based technologies for in vitro selection and evolution of ribozymes and light-up RNA aptamers
TOOLS AND METHODS TO STUDY RIBOZYMES Elucidation of ribozyme mechanisms at the example of the Pistol ribozyme Strategies for crystallization of natural ribozymes NMR spectroscopic investigation of ribozymes Studying Ribozymes with Electron Paramagnetic Resonance Spectroscopy Computational modeling methods for 3D structure prediction of ribozymes
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