Gunnar F. Nordberg, Bruce A. Fowler

Risk Assessment for Human Metal Exposures (eBook, ePUB)

Mode of Action and Kinetic Approaches

• Format: ePub

Produktbeschreibung

Risk Assessment for Human Metal Exposures: Mode of Action and Kinetic Approaches examines the current principles of risk assessment in human metal exposures, with a focus on Mode of Action(MOA), Toxicokinetic and Toxicodynamic (TKTD) considerations, and computer models. Derived from the highly respected Handbook on the Toxicology of Metals, Fourth Edition (2014), the book summarizes principles and methods and provides examples of how MOA -TKTD can be used. In addition, it presents tactics on how information generated by such methods can be confirmed by epidemiological data. Furthermore, it demonstrates how epidemiological data can be confirmed and evaluated by the examined models and considerations.

This resource uniquely integrates several important topics, such as risk assessment, characterization, management and communication-the classic risk assessment paradigm-with mode of action, TKTD, and epidemiology, all topics related to human exposure. Written by pioneers in the field, this book is an essential reference for researchers, students and technicians in toxicology and risk assessment.

• Covers fundamental risk assessment concerns for the effects of metals on human health
• Provides an easy-to-use structure to quickly locate specific methods
• Uses case studies to illustrate the methods and theories described
• Written to be understood by students, researchers and industry workers who need to conduct risk assessment in metals and human health

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 348
• Erscheinungstermin: 21. August 2018
• Englisch
• ISBN-13: 9780128042687
• Artikelnr.: 53785768

Autorenporträt

Dr Gunnar F. Nordberg, MD, PhD, is an emeritus Professor at Umea University, Umea, Sweden, where he served as chairman of the Department of Environmental and Occupational Medicine for many years. He has also worked as a Professor and chair at the Department of Environmental Medicine, Odense University, Denmark and for periods of a year at the International Agency for Research on Cancer, Lyon, France and the University of North Carolina and the National Institute of Environmental Health Sciences, NC, USA. In his capacity as university professor, he tutored many PhD and master students in Environmental medicine, a number of them from countries around the world. He has published more than 280 papers in Scientific Journals and International Handbooks. In addition, he authored, edited or co-edited 24 Scientific Books and participated in International Task Groups evaluating Risks of Environmental Agents, which resulted in 30 international books or reports. Some of these publications resulted from his activities as a chairman of the Scientific Committee on the Toxicology of Metals, International Commission on Occupational Health. He is presently the Task Group Chairman of Cadmium Risk Assessment in the Toxicology and Risk Assessment Group of the International Union of Pure and Applied Chemistry. His Scientific Publications are mainly on Toxicology and Epidemiology of environmental agents, particularly metals and the application of such data for Human Risk Assessment. He has coordinated EU- projects on Environmental Epidemiology and Toxicology of Metals and participated as an active scientist in several such projects. He has been the principal investigator of many research projects funded by Swedish funding Agencies and is presently actively involved in such research. He is one of the editors of a Textbook in Swedish "Arbets- och Miljömedicin¿, latest (3rd) Edition 2010. Chief Editor, Handbook on the Toxicology of Metals, 4th Ed, published 2015 by Academic Press/Elsevier. He has extensive experience as an expert serving Swedish and International Authorities, such as the Swedish National Board of Health (Socialstyrelsen), Japan Food Safety Agency, US Environmental Protection Agency, National Institute of Environmental Health Sciences (NIEHS), Agency for Toxic Substances and Disease Registry (ATSDR) USA, World Health Organization HQ, Geneva/International Program on Chemical Safety/WHO Commission on Health and the Environment, Energy Panel; International Agency for Research on Cancer IARC, Lyon, France, Europe/European Environment Agency, Copenhagen; European Medicines Agency, London; European Food Safety Authority (EFSA), Parma, Italy.

Inhaltsangabe

1. Metal Exposures and Human Health - Historical development, Current Importance and Toxicological Concepts for Prevention2. Exposure, Internal Dose and Toxicokinetics (TK).3. Biomonitoring, Mode of Action (MOA), Target Dose and Adverse Outcome Pathways (AOPs)4. Hazard Identification and Assessment5. Dose-Effect and Dose-Response Assessment6. Dose-Response for Essential Metals and the Evaluation of Mixed Exposures7. Applied Risk Assessment, Hazard Assessment and Risk Management8. Examples of Risk Assessments of Human Metal Exposures and the need for MOA TKTD

Rezensionen

"Risk Assessment for Human Metal Exposures is a timely publication that covers all aspects of risk assessment of metals, and provides a clear description of recent developments, novel approaches, and their application in evaluating risks of exposure to metals, be they essential trace metals purely toxic ones. New approaches covered include toxicokinetic/toxicodynamic models, biomonitoring strategies, Mode of Action (MoA) assessment, and Adverse Outcome Pathways (AOP) approaches, as well as mechanism of action considerations and specific approaches to the use of human data, particularly from epidemiological studies. It is an excellent piece of work, and a recommended read for risk assessment professionals." --Prof. Dr. Maged Younes, Former Director at WHO and UNEP

"This book is an application of the combination of scientific information over time and the rich experience by the authors of risk assessment of metals for the health of humans. I would like to recommend to students, teachers, researchers and scientists working in toxicology and environmental epidemiology" --Taiyi Jin, MD, PhD, Professor and former Chair of the Department of Occupational Health and Toxicology, School of Public Health , Fudan University, Shanghai, China

"It is my pleasure to recommend the book, Risk Assessment for Human Metal Exposure: Mode of Action and Kinetic Approaches by Gunnar F. Nordberg and Bruce A. Fowler. The book is useful for both beginner and the advanced toxicologists. It presents information on the toxicology of metals in relation to human exposure, risk assessment, and health effects of the most widespread metal in occupational settings in a very concise way

...It will be an asset for toxicologists, occupational hygienists, physicians, pharmaceutists, and students who want to broaden their knowledge further, as well as for those experienced readers who need to have access to the most current guidelines and methods of risk assessment.The authors, who are recognized experts in the field of metal toxicology, guarantee up-to-date information and current knowledge." --Natalia Pawlas, MD, PhD, Associate Professor, Medical University of Silesia, Poland, Scientific Committee on Toxicology of Metals, ICOH