RNA Nanotechnology and Therapeutics (eBook, PDF)

Redaktion: Guo, Peixuan; Afonin, Kirill A.

• Format: PDF

Produktbeschreibung

Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in RNA nanotechnology. In addition, the text also provides in-depth discussions of RNA structure for nanoparticle construction, RNA computation and modeling, single molecule imaging of RNA, RNA nanoparticle assembly, RNA nanoparticles in therapeutics, immunorecognition of RNA nanomaterials, RNA chemistry for nanoparticle synthesis, and conjugation and labeling.

• Presents the latest research and discoveries in RNA nanotechnology
• Features contributions from world-class experts in the field
• Covers RNA nanoparticles in therapeutics
• Describes self-assembled RNA nanoparticles

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Produktdetails

• Verlag: Taylor & Francis eBooks
• Seitenzahl: 644
• Erscheinungstermin: 18. Juli 2022
• Englisch
• ISBN-13: 9781000552676
• Artikelnr.: 64215788

Autorenporträt

Peixuan Guo is the Director of the NIH Nanomedicine Development Center at the University of Cincinnati, Ohio and the Director of the NIH/NCI Cancer Nanotechnology Platform Partnership Program: RNA Nanotechnology for Cancer Therapy at Purdue University, Indiana. He is also a Fellow of the National Academy of Inventors. Kirill Afonin is the Professor of Chemistry at University of North Carolina at Charlotte. He currently serves as the Founding Council Member and Vice President of International Society of RNA Nanotechnology and Nanomedicine (isrnn.org) and is recipient of several prestigious awards among which is Maximizing Investigators' Research Award (MIRA R35) from NIH.

Inhaltsangabe

Part I: Concepts and Definitions in RNA Nanotechnology. 1. RNA Structure
and Folding. 2. RNA Regulation and Function in Nature. 3. Principles and
Fundamentals of RNA Nanotechnology. 4. Computation and Folding Predictions.
5. Enzymatic Synthesis and Modification of RNA Nanoparticles. 6. Synthetic
and Enzymatic Methods for RNA Labeling and Modifications. 7. Methods and
Assembly of RNA Nanotechnology. 8. Purification, Characterization, and
Structure Determination of RNA Nanoparticles. 9. SELEX. 10. Uniqueness,
Advantages, Challenges, Solutions, and Perspectives in Therapeutics
Applying RNA Nanotechnology. Part II: Design, Synthesis, and
Characterization Methods in RNA Nanotechnology. 11. The Natural Versatility
of RNA. 12. Nucleic Acids as a building material in nanotechnology. 13.
Multiple functionalities for RNA Nanoparticles. 14. From Computational RNA
Structure Predication to the Design of Biologically Active RNA-based
Nanostructures. 15. Application of RNA tertiary structure prediction tool
iFoldRNA in RNA nanotechnology. 16. HyperFold: A Web Server for Predicating
Nucleic Acid Complexes. 17. RNA Switches: Towards Conditional Dynamic
RNA-based Constructs for Therapeutics and Bioassays. 18. RNA Multiway
Junction Motifs as Lego for Construction of Multifunctional RNA
Nanoparticles. 19. Fabrication Methods for RNA Nanoparticle Assembly Based
on Bacteriophage Phi29 PRNA Structural Features. 20. Purification of RNA,
modified oligos and RNA nanoparticles. 21. Physicochemical Characterization
of Nucleic Acid Nanoparticles. 22. Light Scattering Techniques for
Characterization of NANPs and Their Formulations. 23. Electron Microscopy
of Nucleic Acid Nanoparticles. 24. A Single FRET Approach for Investigating
the Binding Mechanism of Anti-viral Aptamers. 25. Entropy and Enthalpy in
RNA Nanoparticle Assembly and Thermodynamic Stability for Medical
Application Using RNA Nanotechnology. Part III: Immunorecognition of RNA
Nanoparticles. 26. Immunorecognition of nucleic acid nanoparticles. 27.
Viral noncoding RNAs in modulating cellular defense and their potential for
RNA nanotechnology. 28. RIG-I as a therapeutic target for Nucleic Acid
Nanoparticles (NANPs). 29. Driving Dynamic Functions with Programmable RNA
Nanostructures. 30. Use of human peripheral blood mononuclear cells to
define immunological properties of nucleic acid nanoparticles. Part IV:
Delivery of Functional RNA Nanoparticles. 31. The emerging field of RNA
Nanotechnology. 32. Thermodynamically stable RNA three-way junction for
constructing multifunctional nanoparticles for delivery of therapeutics.
33. RNAi Nanotherapeutics for Localized Cancer Therapy. 34. Delivery of RNA
nanoparticles. 35. Recommendations for Planning in vivo Studies for RNAi
Therapeutics. 36. Mesoporous silica nanoparticles for efficient siRNA
delivery. 37. Method of Large-scale Exosome Purification and Its Use for
Pharmaceutical Applications. 38. Engineered extracellular vesicle based
therapeutics for liver cancer. 39. Extracellular Vesicles: An innovative
approach to engineering nucleic acid delivery. 40. Extracellular Vesicles
(EVs): Naturally Occurring Vehicles for RNA Nanotherapeutics. 41.
Harnessing exosomes and bioinspired exosome-like nanoparticles for siRNA
delivery. Part V: Application and Exploitation in RNA Nanotechnology. 42.
RNA structural modeling for therapeutic applications. 43. RNA micelles for
therapeutics delivery and cancer therapy. 44. Bacteriophage RNA Leading the
Way in RNA Nanotechnology for Targeted Cancer Therapy. 45. Current State in
development of RNAi self-assembled nanostructures. 46. RNA-Based Devices
for Diagnostic and Biosensing. 47. MicroRNAs: Biology and Role in RNA
Nanotechnology. 48. Conjugation of RNA aptamer to RNA nanoparticles for
targeted drug delivery. 49. MicroRNAs in human cancers and therapeutic
applications. 50. Tuning the Size, Shape and Structure of RNA Nanoparticles
for Favorable Cancer Targeting and Immunostimulation. 51. Application of
RNA nanotechnology in Exosome for gene therapy. 52. Application of RNA
Aptamers in Nanotechnology and Therapeutics.