Selective Estrogen Receptor Modulators (eBook, PDF)

Research and Clinical Applications
Redaktion: Manni, Andrea; Verderame, Michael

• Format: PDF

Produktbeschreibung

Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain. In Selective Estrogen Receptor Modulators: Research and Clinical Applications, leading experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of coactivators and corepressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentations review the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A novel approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer. Multidisciplinary and state-of-the-art, Selective Estrogen Receptor Modulators: Research and Clinical Applications provides experimentalists and clinicians alike a comprehensive overview of the basic mechanisms of estrogen and SERMs action, as well as evidence-based guidelines for their clinical use in postmenopausal women.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 374
• Erscheinungstermin: 18. Januar 2002
• Englisch
• ISBN-13: 9781592591572
• Artikelnr.: 44179403

Inhaltsangabe

I Molecular Mechanisms of Estrogen Receptor Function.- 1 Structure and Function of the Estrogen Receptor.- 2 Ligand-Induced Conformational Changes in Estrogen Receptors-? and -?.- 3 Expression and Function of Estrogen Receptors-? and -?.- 4 SERM Modulation of Gene Expression: Role of Coactivators and Corepressors.- 5 Crosstalk Between Estrogen Receptors and Growth Factor Signaling.- II Tissue-Specific Effects of Estrogens and SERMs.- 6 Direct Estrogen Effects on the Cardiovascular System.- 7 Estrogens and the Brain: Implications for the Treatment of Postmenopausal Women.- III Preclinical Studies.- 8 Insights into the Molecular Mechanism of SERMs Through New Laboratory Models.- 9 Third- and Fourth-Generation SERMs.- IV Organ Specific Effects of Estrogens and SERMs.- 10 SERMs' Effect on the Neuroendocrine System and the Reproductive Organs.- 11 Epidemiology of Cardiovascular Disease in Women: Role of Estrogens.- 12 SERMs Effects on Cardiovascular Risk Factors and Disease.- 13 Estrogen and the Skeleton.- 14 Effects of SERMs on Bone in Clinical Studies.- 15 Estrogens and SERMs: Clinical Aspects of Cognition with Aging and Neurodegenerative Disorders.- V SERMs and Endocrine Dependent Tumors.- 16 SERMs and Breast Cancer Prevention.- 17 SERMs in Postmenopausal Women's Health.- VI Roles of Estrogens and SERMs in Postmenopausal Hormone Replacement Therapy.- 18 Menopause Therapy: An Individualized Approach.- 19 Alternatives to Estrogen for Treatment of Menopause.- 20 Phytoestrogens in the Context of SERMs.

Rezensionen

"...this book is densely packed with data will be valuable for investigators in the field as well as those new to this area. There are many details of interest to the molecular endocrinologist. The clinical information is also intriguing for the clinician who needs to know how to apply the SERMs in the management of postmenopausal problems." - Oncology

"Selective Estrogen Receptor Modulators: Research and Clinical Application is an indispensable resource for evaluating the use of SERM potential alternatives to estrogens. The book synthesizes the current understanding of SERM at the levels of molecular mechanisms and clinical applications and provides a precise and balanced view of ongoing research and future developments. Clearly written and supported by informative illustrations, it is aimed at a specialized audience and should be particularly useful to researchers and clinicians eager to advance their knowledge of these so-called 'designer estrogens'. Selective Estrogen Receptor Modulators is an excellent collection of timely reviews. Its major strength is combining basic and clinical studies in a thorough account of current knowledge about estrogens and SERM." -Trends in Endocrinology and Metabolism