Signal Transduction: Pathways, Mechanisms and Diseases (eBook, PDF)

Redaktion: Sitaramayya, Ari

• Format: PDF

Produktbeschreibung

Anotherareacoveredinthisbook,onenotoftenhighlightedinsignaltransd- tionbooks,isthatofsignalingplatforms,whichisemergingasasigni?cantareaof researchrelevanttocellularmetabolism,cellproliferation,differentiation,apop- sis,neurodegenerativediseases,andcancer. Theauthorscontributingtothisbook vii viii Preface areexpertsandactivecontributorstoresearchintheirspeci?careasofsignaling. I would like to thank them for their contributions and their suggestions in the developmentofthebook. IwouldliketoacknowledgethehelpofFrankTedeschi, astudentinmydepartment,whoassistedineditingthemanuscriptsandinprep- ingtheindex. IwouldalsoliketothankDr. SabineSchwarz,LifeSciencesEditorat SpringerVerlag,andDr. JuttaLindenbornwhohavebeenveryhelpfulatevery stageofproductionofthisbook. AriSitaramayya Contents PartI GProteinsandGProtein-CoupledReceptors 1 TraditionalGPCRPharmacologyandBeyond. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 AnnetteGilchristandMariaR. Mazzoni 2 RegulationofIntraneuronalTraf?ckingofG-Protein-Coupled ReceptorsbyNeurotransmittersInVivo . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 Ve¿roniqueBernard 3 SmallGTPasesandTheirRoleinRegulatingGProtein-Coupled ReceptorSignalTransduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 43 FabiolaM. RibeiroandStephenS. G. Ferguson 4 RegulationofGProteinReceptorCoupling,MoodDisorders andMechanismofActionofAntidepressants . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63 MoranGolan,GabrielSchreiber,andSo?aAvissar 5 DysregulationofGProtein-CoupledReceptorSignaling inCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 83 JoAnnTrejo PartII GrowthFactors 6 InsulinSignalinginNormalandDiabeticConditions . . . . . . . . . . . . . . . . . 101 PatriceEFort,HisanoriImai,RajuRajala,andThomasW. Gardner 7 EpidermalGrowthFactor(EGF)ReceptorSignaling andCancer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 119 ElizabethS. HensonandSpencerB. Gibson ix x Contents 8 LeptinSignalingPathway. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 143 HiroyukiShimizu 9 SignalinginNormalandPathologicalAngiogenesis. . . . . . . . . . . . . . . . . . 159 MichaelR. MancusoandCalvinJ. Kuo PartIII SignalingPlatforms 10 SpatialandTemporalControlofCellSignaling byA-KinaseAnchoringProteins. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 183 F. DonelsonSmith,LoreneK. Langeberg,andJohnD. Scott 11 Mitochondria,aPlatformforDiverseSignalingPathways . . . . . . . . . . 199 AstridC. SchaussandHeidiM. McBridee 12 Mitogen-ActivatedProteinKinases andTheirScaffoldingProteins . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 219 DannyN. DhanasekaranandE. PremkumarReddy 2þ 13 MolecularandFunctionalDeterminantsofCa SignalingMicrodomains . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 237 InduS. Ambudkar,HweiL. Ong,andBrijB. Singh PartIV NuclearReceptors/Transcription 14 EukaryoticGeneTranscription . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 257 JenniferH. GromekandArikDvir 15 EstrogenSignalingMechanisms. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 273 DapengZhangandVanceL. Trudeau 16 SignalTransductionPathwaysInvolved inGlucocorticoidActions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 289 PeterJ. Barnes PartV ReactiveSignalingMolecules 17 CellularSignalingbyReactiveOxygenSpecies:Biochemical BasisandPhysiologicalScope . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 313 ^ ¿ MichelB. Toledano,SimonFourquet,andBeno?tD'Autreaux 18 SolubleGuanylylCyclase:TheNitricOxideReceptor. . . . . . . . . . . . . . . 337 DorisKoeslingandAriSitaramayya Contents xi PartVI CellCycle,CellDeathandCancer 19 DistinctRolesofthePocketProteinsintheControl ofCellCycle. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 353 ParaskeviVogiatziandPierPaoloClaudio 20 Activationofthep53TumorSuppressoranditsMultipleRoles inCellCycleandApoptosis. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375 LucianaE. GionoandJamesJ. Manfredi 21 AgingandCancer:CaretakersandGatekeepers . . . . . . . . . . . . . . . . . . . . . 397 DianavanHeemst 22 SignalTransductioninEmbryonicStemCells andtheRiseofiPSCells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 437
• Erscheinungstermin: 2. Dezember 2009
• Englisch
• ISBN-13: 9783642021121
• Artikelnr.: 37366037

Inhaltsangabe

G Proteins and G Protein-Coupled Receptors.- Traditional GPCR Pharmacology and Beyond.- Regulation of Intraneuronal Trafficking of G-Protein-Coupled Receptors by Neurotransmitters In Vivo.- Small GTPases and Their Role in Regulating G Protein-Coupled Receptor Signal Transduction.- Regulation of G Protein Receptor Coupling, Mood Disorders and Mechanism of Action of Antidepressants.- Dysregulation of G Protein-Coupled Receptor Signaling in Cancer.- Growth Factors.- Insulin Signaling in Normal and Diabetic Conditions.- Epidermal Growth Factor (EGF) Receptor Signaling and Cancer.- Leptin Signaling Pathway.- Signaling in Normal and Pathological Angiogenesis.- Signaling Platforms.- Spatial and Temporal Control of Cell Signaling by A-Kinase Anchoring Proteins.- Mitochondria, a Platform for Diverse Signaling Pathways.- Mitogen-Activated Protein Kinases and Their Scaffolding Proteins.- Molecular and Functional Determinants of Ca2+ Signaling Microdomains.- Nuclear Receptors / Transcription.- Eukaryotic Gene Transcription.- Estrogen Signaling Mechanisms.- Signal Transduction Pathways Involved in Glucocorticoid Actions.- Reactive Signaling Molecules.- Cellular Signaling by Reactive Oxygen Species: Biochemical Basis and Physiological Scope.- Soluble Guanylyl Cyclase: The Nitric Oxide Receptor.- Cell Cycle, Cell Death and Cancer.- Distinct Roles of the Pocket Proteins in the Control of Cell Cycle.- Activation of the p53 Tumor Suppressor and its Multiple Roles in Cell Cycle and Apoptosis.- Aging and Cancer: Caretakers and Gatekeepers.- Signal Transduction in Embryonic Stem Cells and the Rise of iPS Cells.- Erratum to.