Signaling Pathways in Squamous Cancer (eBook, PDF)

Redaktion: Glick, Adam B.; Waes, Carter Van

• Format: PDF

Produktbeschreibung

Squamous epithelia form the lining surface of tissues in contact with the environment: the skin, oral mucosa, esophagus and respiratory tract, the genital tract, and several other specialized tissues. These tissues are at highest risk for exposure to environmental carcinogens such as UV, tobacco smoke and infectious agents. Cancers that form in squamous epithelia are among the most common human solid tumors and have high morbidity and mortality. These cancers include squamous cell carcinoma of the skin, oral cancer, head and neck and esophageal cancer, certain lung cancers and cervical cancer.

We propose to organize the book so that the early chapters will focus on individual pathways and more specific mechanisms in both normal function and cancer, while the later chapters will be more integrative and include overviews of biomarkers and therapeutic development. This should increase interest for clinically oriented researchers. All authors will be encouraged to provide a balanced review in addition to highlighting their own work.

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Produktdetails

• Verlag: Springer US
• Seitenzahl: 462
• Erscheinungstermin: 25. November 2010
• Englisch
• ISBN-13: 9781441972033
• Artikelnr.: 37357974

Inhaltsangabe

1. Regulation of Squamous Differentiation

p63

Dennis Roop

Wendy Weinberg, FDA

Notch

Raphael Kopan, Washington University School of Medicine St. Louis

Michael Parmacek, U. Penn

beta-catenin/wnts

Elaine Fuchs: Rockefeller

Fiona Watt Cambridge Research Institute , UK

Sarah Millar: U. Penn

AP1

Peter Angel, German Cancer Research Center

T.Bowden (UV and AP1) University of Arizona

Nuclear Hormone receptors

PPAR: Jeff Peters, Penn State

NF-kB: M. Karin, UCSD

2. Regulation of Proliferation and Survival

EGFR family

J. Grandis Pittsburgh

L. Hansen, Creighton University

Stats

J. DiGiovanni, MD Anderson

TGF

Michael Reiss

Elaine Fuchs Rockefeller

Adam Glick, Penn State

p53/p63/p73

3. Regulation of Inflammatory Signaling

Carter Van Waes, NCI

D. Hanahan, UCSF

Lisa Coussens, UCSF

4. Regulation of Migration, Invasion, Matrix and Basement Membrane Interactions and Metastasis

Integrin signaling

Arthur Mercurio: Harvard University

MET signaling in migration and angiogenesis

Zhong Chen and Gang Dong: NIDCD and NIAID

Matrix production and degradation

Eben Rosenthal, Univeristy of Alabama

Lynn Matrisian, Vanderbilt

5. Integration of aberrant signaling in transcriptional dysregulation of gene and protein expression in squamous cell carcinoma

Zhong Chen, Bin Yan and Carter Van Waes

6. Effects and therapeutic potential of targeting dysregulated signaling axes in squamous cell carcinoma

EGFR, SRC, STAT3: Jennifer Grandis and coauthors

NF-kappaB: Clint Allen, Liesl Nottingham and Carter Van Waes

P16, p53, p63: James Rocco and Leif Ellisen, Harvard

AKT and mTOR: Silvio Gutkind, NIDCR and Cherie-Ann O Nathan,

PPAR:Frank Ondrey and Eva Szabo, University Minnesota, NCI