Smart Organ-on-Chip Devices (eBook, ePUB)

Dynamic Microfluidic Systems for Cell Culture
Redaktion: Balbino, Tiago Albertini; Charelli MSc, Letícia; Bartolo, Paulo

• Format: ePub

Produktbeschreibung

Smart Organ-on-Chip Devices: Dynamic Microfluidic Systems for Cell Culture discusses the concepts to engineer functional stimuli responsive organotypic-on-chip devices and its application in several fields, including drug development, disease modeling, personalized medicine, and tissue engineering. Groundbreaking studies are presented throughout the book sections to reinforce the importance of adding more reliable and robust in vitro platforms able to closely emulate the dynamism of human physiology.The authors present new information regarding in silico studies of cell spheroids within microfluidic devices, as well as step-by-step guidance on key procedures. Written for researchers, practitioners and students using microfluidic devices as platforms, by well-respected scientists from both academia and industry. - Presents the physiological relevance of in vitro tissue-like models - Introduces evidence that stimuli-responsive organotypic-on-chip devices are the next generation - Provides latest achievements to attain an organ-on-chip device, as well as case studies

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Produktdetails

• Verlag: Elsevier Science & Techn.
• Seitenzahl: 250
• Erscheinungstermin: 25. April 2025
• Englisch
• ISBN-13: 9780443134043
• Artikelnr.: 73965764

Inhaltsangabe

SECTION 1: MICROFLUIDICS AND ORGAN-ON-CHIP TECHNOLOGIES
1. Organotypic On-Chip Models: Bridging the Gap Between Traditional In
Vitro Culture and Animal Testing
2. Microfabrication Processes for the Manufacturing of Smart Organ-on-Chip
Devices
3. Bioprinted Organ-on-a-Chip: A Strategy to Achieve Humanized In Vitro
Models
4. Disease Modeling and Developmental Biology Through Microfluidic Channels
5. Artificial Intelligence-Assisted Organ-on-Chip Systems
SECTION 2: STIMULI ACTIVE ORGANOTYPIC-ON-CHIP DEVICES
6. Mechanically Active Organotypic-On-Chip Devices for Dynamic Cell Culture
7. Sensors within Microfluidic Chips: Optofluidics to Explore In Vitro
Organoid Behavior
8. Photothermal and Magnetic Cell Stimuli Caused by Nanoparticles Inside
Organ-on-Chip Platforms
SECTION 3: MICROPHYSIOLOGICAL CASE STUDIES
9. Brain-on-Chip Microplatforms for Precision Medicine, Disease Modelling,
and Developmental Biology
10. Dynamic Microphysiological Systems to Access Sickle Cell Disease - A
Case Study for Disease Modeling
11. Microtechnologies and Mathematical Modeling in Signaling Cascades
Multiorgan Microphysiological Systems
12. Mechanically Active Heart-on-a-Chip: Toward a Reliable Heart Beating
Study Model
13. Remaining Challenges: Are We Close to a Physiologically Representative
In Vitro Model for Clinical Deployment?