Borivoj Keil

Specificity of Proteolysis (eBook, PDF)

• Format: PDF

Produktbeschreibung

Detailed information about the specificity of more than 280 protein cleaving enzymes - important tools for protein analysis - are presented in the book.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 336
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642483806
• Artikelnr.: 52835227

Autorenporträt

Detailed information about the specificity of more than 280 protein cleaving enzymes - important tools for protein analysis - are presented in the book.

Inhaltsangabe

1 Introduction.- 2 Nomenclature and Conventions.- 2.1 EC Numbers.- 2.2 Enzyme Names.- 2.3 Enzyme and Substrate Codes.- 2.4 Subsite Nomenclature.- 2.5 Bibliography.- 3 Data Treatment.- 3.1 Data Bank LYSIS.- 3.2 Statistical Approach to Specificity.- 4 Standard Polypeptide Substrates.- 4.1 Choice of Standard Polypeptides.- 4.2 Available Data on Cleavages of Insulin Chains and Glucagon.- 4.3 Repartition of Cleavage-Susceptible Bonds.- 4.4 Binding Sites - Proposal for Fixation Site Types.- 4.5 Influence of Subsites.- 5 Essential Substrate Residues for Action of Endopeptidases.- 5.1 Basic Residue.- 5.2 Acidic Residue.- 5.3 Neutral Residue.- 5.4 Proline Residue.- 5.5 Alpha-Epsilon Peptide Bond.- 5.6 Peptidases with Occasional Endopeptidase Activity.- 5.7 Vague or Insufficient Information on Specificity.- 5.8 No Information on Bond Specificity.- 6 Comments.- 6.1 Frequently Used Proteinases and Restriction Proteinases.- 6.2 Group of Microbial Proteinases.- References.- Appendices.- A Tabular Index of LYSIS Enzyme Codes.- B Tabular Index of LYSIS Protein Codes.