Jozef Nauta

Statistics in Clinical Vaccine Trials (eBook, PDF)

• Format: PDF

Produktbeschreibung

- First comprehensive text on the current state of the statistical methodology for clinical vaccines trials - Many worked-out real-life examples - SAS codes for the more complex examples provided

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 153
• Erscheinungstermin: 7. Oktober 2010
• Englisch
• ISBN-13: 9783642146916
• Artikelnr.: 37368955

Inhaltsangabe

Basic Concepts of Vaccine Immunology.- Humoral and Cellular Immunity.- Standard Statistical Methods for the Analysis of Immunogenicity Data.- Antibody Titres and Two Types of Bias.- Adjusting for Imbalance in Pre-vaccination State.- Vaccine Equivalence and Non-Inferiority Immunogenicity Trials.- Vaccine Field Efficacy Trials.- Correlates of Protection.- Safety of Vaccines.- Appendices: SAS and Floating Point Format for Calculated Variables.- Closed-Form Solutions for the Constrained ML Estimators Ro.- Simulation Results on Jewell's Correction for the Rate Ratio.- Proof of Inequality.- A Generalized Worst-Case Sensitivity Analysis for a SingleSeroresponse Rate for Which the Confidence Interval Must Fall Above a Pre-Specified Bound.

Rezensionen

From the book reviews:

"The presentation of the book is lucid. The author is to be congratulated for mixing his vast practical experience with his knowledge to make this book readable and practically valuable." (Subir Ghosh, Technometrics, Vol. 55 (3), August, 2013)