Kenneth Kee

Stiff Person Syndrome, A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions (eBook, ePUB)

• Format: ePub

Produktbeschreibung

This book describes Stiff Person Syndrome, Diagnosis and Treatment and Related Diseases

Unlike the Fibrodysplasia ossificans progressiva (Stone Man Syndrome) which I wrote about a few months ago, this stiff man syndrome is more an autoimmune disease of the neurological disorder that affects the brain and spinal cord causing the person to be stiff due to muscle spasms.

Fibrodysplasia ossificans progressiva (Stone Man Syndrome) in contrast is a genetic disorder in which muscle and connective tissue such as tendons and ligaments are slowly replaced by bone (ossified), producing bone outside the skeleton (extra-skeletal or heterotopic bone) that restricts movement.

They are completely different disorders.

Stiff person syndrome (SPS) is a rare, progressive medical disorder that involves the nervous system, specifically the brain and spinal cord.

Stiff person syndrome (SPS) is called an autoimmune neurological disorder.

Like other types of neurological disorders, SPS affects the brain and spinal cord (central nervous system).

An autoimmune disorder happens when the immune system incorrectly identifies normal body tissues as harmful and attacks them.

SPS is rare.

It can significantly affect the quality of life without proper treatment

Symptoms may involve extreme muscle stiffness, rigidity and painful spasms in the trunk and limbs, seriously impairing mobility.

Spasms can generate enough force to fracture bone.

People with SPS often have increased sensitivity to noise, sudden movements, and emotional distress, which can activate muscle spasms.

Continual symptoms can cause abnormal posturing of the spine, such as being hunched over.

The precise cause of SPS is not known.

It is possibly genetic.

It is thought to have an autoimmune component and is often linked with diabetes, and other autoimmune diseases such as thyroiditis, vitiligo, and pernicious anemia.

The patient may also be at an increased risk for developing the syndrome if the patient or someone in the family has another type of autoimmune disease.

These are:
1. Type 1 and 2 diabetes
2. Pernicious anemia
3. Rheumatoid arthritis
4. Thyroiditis
5. Vitiligo

For unknown causes, autoimmune diseases fight the healthy tissues in the body.

With SPS, the tissues in the brain and spinal cord are involved.

This causes symptoms based on the tissue that is attacked.

SPS produces antibodies that assail proteins in brain neurons that regulate muscle movements.

These are called glutamic acid decarboxylase antibodies (GAD).

It may be diagnosed after having various tests including blood tests (including a test showing elevated glutamic acid decarboxylase (GAD) antibodies), a lumbar puncture, and electromyography.

The treatment focuses on the control of symptoms and improvement of mobility, and may require benzodiazepines, muscle relaxants, and intravenous immunoglobulin (IVIG).

While some people with SPS may sustain reasonable amounts of activity with treatment, the majority of them become disabled over time.

The symptoms of stiff person syndrome may form when the immune system mistakenly attacks the neurons that produce GAD.

When GAD is not working properly, there is not adequate GABA to help control muscle movement.

The precise part that deficiency of GAD plays in the development of stiff person syndrome is not fully known.

Some patient with stiff person syndrome will have antibodies to amphiphysin, a protein involved in the communication of signals from one neuron to another.

Persons with these antibodies have a higher danger for developing breast, lung, or colon cancer

TABLE OF CONTENT
Introduction
Chapter 1 Stiff Person Syndrome
Chapter 2 Causes
Chapter 3 Sympto...

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Produktdetails

• Verlag: Kenneth Kee
• Erscheinungstermin: 26. Dezember 2019
• Englisch
• ISBN-13: 9780463930755
• Artikelnr.: 75904495

Autorenporträt

Dr. Kenneth Kee is a well-known medical doctor from Singapore who has been practicing medicine since 1972.
He graduated from the University of Singapore and furthered his studies with a Master of Science in Health Management in 1991, followed by a Ph.D. in Healthcare Administration in 1993.
Dr. Kee established Kee Clinic in 1974, located in the Holland Drive area of Singapore. The clinic has been a prominent feature of the community, offering general medical services for 5 decades.
Dr Kee also served his country Singapore as a national service police Inspector at night from 1975 to 1985 while working at his clinic during the day.
He had served as a police guard to the Woodland Petroleum Tanks at night during the Indonesian Confrontation period, took part in police rounds at night in the Beach Road area and taught First aid and emergency resuscitation to Police recruits.
He received the Singapore Police Bicentennial 2020 Medallion on 1st March 2024 as recognition for his work in the Singapore Police.
Even as he grew older, Dr. Kee continued to work actively in his clinic, although he eventually reduced his consultation hours.
Beyond his medical career, Dr. Kee is also an author.
He started writing about medical conditions in 2007, using blogs and other online platforms to share his knowledge with a broader audience.
Over time, he published various books, many of which provide simple and accessible guides to different health conditions.
His works include "A Family Doctor's Tale," "My Personal Singapore History," and numerous medical guides, available through platforms like Amazon.
His books often combine his personal experiences as a family doctor with insights into Singapore's healthcare system and history.
Dr. Kee has written extensively on health topics, contributing to both medical literature and general knowledge resources.

Dr. Kenneth Kee has written numerous books, primarily focused on health education and personal experiences as a family doctor. Some of his notable titles include:
"A Family Doctor's Tale"
This book is a blend of Dr. Kee's personal experiences and his reflections on being a family doctor in Singapore. It's a great choice if you're looking for a narrative that combines both medical knowledge and human stories.
"Specialized Medical Conditions"
Books like **"Congestive Heart Failure: Diagnosis and Treatment"** focus on specific conditions, offering in-dept...