The Lock-and-Key Principle (eBook, PDF)

The State of the Art--100 Years On
Redaktion: Behr, Jean-Paul

• Format: PDF

Produktbeschreibung

Published 100 years after Emil Fischer first proposed the lock-and-key principle, this volume provides a complete review of the subject to date and offers suggestions for futher research. The major impact of the lock-and-key principle on the chemical, biomedical and materials sciences is discussed by leaders in the field, with chapters dedicated to molecular recognition, nucleic acid and protein chemistry, crystallography and the development of Emil Fischer's initial ideas. The Lock-and-Key Principle is the most up-to-date review of progress in supramolecular chemistry and the lock-and-key principle and will become the essential guide to the past, present and future of this remarkable principle.

---

Dieser Download kann aus rechtlichen Gründen nur mit Rechnungsadresse in D ausgeliefert werden.

Produktdetails

• Verlag: John Wiley & Sons
• Erscheinungstermin: 30. April 2008
• Englisch
• ISBN-13: 9780470511404
• Artikelnr.: 38198592

Autorenporträt

Jean-Paul Behr is the editor of The Lock-and-Key Principle: The State of the Art--100 Years On, published by Wiley.

Inhaltsangabe

Contributors vii
Preface ix
1 Emil Fischer's Lock-and-Key Hypothesis after 100 Years-Towards a
Supracellular Chemistry 1
Friedrich Cramer
2 Molecular Recognition in Biology: Models for Analysis of Protein-Ligand
Interactions 25
Doron Lancet, Amnon Horovitz and Ephraim Katchalski-Katzir
3 New Biocatalysts via Chemical Modification 73
Ian M. Bell and Donald Hilvert
4 Oligonucleotides: Superspecific Ligands for Targeting Nucleic Acids and
Proteins and Development of Molecular Devices 89
V. V. Vlassov
5 Macrocycles and Antibodies as Catalysts 149
D. B. Smithrud and S. J. Benkovic
6 Lock-and-Key Processes at Crystalline Interfaces: Relevance to the
Spontaneous Generation of Chirality 173
Isabelle Weissbuch, Ronit Popovitz-Biro, Leslie Leiscrowitz and Meir Lahav
7 A Model of the Origin of Life and Perspectives in Supramolecular
Engineering 247
H. Kuhn and J. Waser
8 Perspectives in Supramolecular Chemistry-From the Lock-and-Key Image to
the Information Paradigm 307
Jean-Marie Lehn
Index 319