The Macrophage as Therapeutic Target (eBook, PDF)

Redaktion: Gordon, Siamon

• Format: PDF

Produktbeschreibung

Timely reviews of molecules and cellular properties considering role of macrophages in disease which could be exploited to develop new drugs. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. Overall, the volume should provide a broad sample of the state of the art, including complex, neglected areas eg lipid diseases. Useful reviews and references in the literature are cited within individual chapters. Suitable for graduates up, beneficial to postdocs, experimental scientists (academic and industry) and clinicians, including immunologists and pathologists.

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Produktdetails

• Verlag: Springer Berlin Heidelberg
• Seitenzahl: 496
• Erscheinungstermin: 6. Dezember 2012
• Englisch
• ISBN-13: 9783642557422
• Artikelnr.: 53381302

Inhaltsangabe

List of Contents.- 1. General.- The Macrophage as a Validated Pharmaceutical Target.- Transcription Factors that Regulate Macrophage Development and Function.- Exploitation of Macrophage Clearance Functions In Vivo.- Reaching the Macrophages: Routes of Delivery.- Antigen Presenting Cells and Vaccine Design.- Macrophage-Specific Gene Targeting In Vivo.- 2. Macrophage Targets in Inflammation.- Integrins of Macrophages and Macrophage-Like Cells.- Macrophage Targets in Inflammation: Purinergic Receptors.- Macrophage Lipid Uptake and Foam Cell Formation.- Dietary Fatty Acids and Macrophages.- Macrophages as Therapeutic Targets in Lysosomal Storage Disorders.- Nuclear Receptors as Regulators of Macrophage Homeostasis and Function.- Relationships between Reactive Oxygen Species and Reactive Nitrogen Oxide Species Produced by Macrophages.- Proteases.- Targeting the Chemokine System.- Antimicrobial Peptides.- Macrophage Phospholipid Products.- 3. Modulation of Specialised Macrophage Activities.- Dendritic Cells Versus Macrophages as Antigen-Presenting Cells: Common and Unique Features.- The Osteoclast.- Macrophages in the Central and Peripheral Nervous System.- Innate Recognition of Viruses by Macrophage and Related Receptors: Potential Ligand for Antiviral Agents.- Macrophage Immunity and Mycobacterium Tuberculosis.- Detection and Control of Fungi by Macrophages: The Role of Carbohydrates and Antifungal Agents.