The Metabolic Syndrome: (eBook, PDF)

Epidemiology, Clinical Treatment, and Underlying Mechanisms
Redaktion: Hansen, Barbara C.; Bray, George A.

• Format: PDF

Produktbeschreibung

With an extraordinary need for early intervention and prevention to slow or halt its progression, metabolic syndrome is one of the most challenging health problems. Only through an understanding of the science underlying this syndrome can successful interventions be developed and implemented.

This book covers the most important clinical and bench science aspects of metabolic syndrome. Coverage includes updated clinical views on the syndrome, its definition, current and future treatment options, and a critical evaluation of the current status of each of the syndrome components, including the latest knowledge of casual mechanisms.

The writers stimulate new thinking concerning the underlying mechanisms and encourage heightened efforts to develop new therapeutics, potentially targeting uniquely intersecting pathways.

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Produktdetails

• Verlag: Humana Press
• Seitenzahl: 402
• Erscheinungstermin: 6. Mai 2010
• Englisch
• ISBN-13: 9781603271165
• Artikelnr.: 44121086

Inhaltsangabe

Metabolic Syndrome-Past and Future.- Metabolic Syndrome-Past and Future.- Epidemilogy And Clinical Treatment: Issues In Defining And Treating The Metabolic Syndrome.- Metabolic Syndrome.- The Role of Obesity in Insulin Resistance.- Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery.- Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease.- The Sympatho-Adrenal System in the Metabolic Syndrome.- Endothelial Function, Inflammation, and Dyslipidemia.- Insulin Action and Endothelial Function.- Macro- and Microvascular Disease in an Insulin-Resistant Pre-Diabetic Animal Model.- High-Sensitivity C-Reactive Protein and the Metabolic Syndrome.- Insulin Signaling in Adipocytes and the Role of Inflammation.- Insulin Resistance and Dyslipidemia.- Insulin-Secretion and Action: Underlying Mechanisms of the Metabolic Syndrome.- Pancreatic Islet Pathophysiology and Pathology in Obesity.- Glucagon-like Peptides and Insulin Sensitivity.- The Relationship Between the Insulin Receptor Substrates and Metabolic Disease.- Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase.- Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance.- Alterations in Atypical Protein Kinase C Activation in Insulin Resistance Syndromes.- The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus.- Chronomics of the Metabolic Syndrome.

Rezensionen

From the reviews:

"This book presents a balanced view of the controversies surrounding the metabolic syndrome and supplies the reader with a detailed account of the key issues that divide the various camps. ... is an admirable collection of scientifically focused and up-to-date views of the current thinking on the metabolic syndrome. It can be recommended for scientists working in this field as well as for clinicians who wish to gain a deeper understanding of this complex syndrome." (Arne Astrup, The New England Journal of Medicine, July, 2008)

"This book covers three major perspective of the metabolic syndrome ... . this book is written for an endocrinology audience and anyone who has a strong interest in the link between the basic science of insulin resistance and the clinical manifestations of the metabolic syndrome. Practitioners will find useful information about the underlying mechanisms of the disease as well as an overview of treatment approaches. ... This is a high quality review of insulin resistance targeted at endocrinologists and basic scientists." (Matthew J. Sorrentino, Doody's Review Service, November, 2008)